Low dose-extended letrozole versus double dose-short letrozole protocol for ovulation induction in polycystic ovary syndrome

Background: Letrozole, an aromatase inhibitor has been regarded as the first line drug for ovulation induction in anovulatory PCOS patients because of its monofollicular growth and there is no chance hyperstimulation by letrozole. Traditional protocol letrozole includes administration 5 days half follicular phase which induces 61.7% cases. Few recent studies have shown that extended causes more follicles to grow than traditional protocol. The aim was compare effects low dose-extended double dose-short infertile patients.Methods: A randomized controlled trial (RCT) conducted department reproductive endocrinology Infertility at Bangabandhu Sheikh Mujib Medical University (BSMMU) on seventy polycystic ovary syndrome patients. Low group or experimental received tablet 2.5 mg daily 10 control tab. Letrozole starting from 2nd day menstrual cycle withdrawal bleeding. ovarian response assessed folliculometry 12 transvaginal sonography measurement total number growing follicles, biggest follicle size endometrial thickness. Mid luteal serum progesterone measured 21-23 confirm ovulation.Results: mean 1.440.95 versus 0.990.65 respectively generating p value 0.001. dominant greater other displaying 17.69±3.63 mm 16.6±3.49 but difference not statistically significant. ovulating (76.5% 71.9%), without significant statistical difference. Pregnancy rate insignificantly (23.5% 18.8%) well.Conclusions: produces multifollicular larger with a trend raise pregnancy rate, though insignificantly.